Grand Ohio River (St. Louis to Pittsburg)

📅 Friday, June 19, 2026 🏁 Saturday, July 4, 2026 🌙 14 Nights Saint Louis, Missouri 🚢 American Melody
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Route Map

Day-by-Day Itinerary

Day 1
Saint Louis, Missouri United States Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive 2026-06-19 00:00:00
Day 2
🌊 At Sea
Day 3
Paducah, Kentucky United States Explore America's largest collection of outdoor murals transforming riverside walls into an open-air art gallery.
Arrive 2026-06-21 00:00:00
Day 4
🌊 At Sea
Day 5
Henderson, Kentucky United States Explore the historic John James Audubon State Park and museum to discover wildlife artistry and Kentucky heritage along the scenic Ohio River.
Arrive 2026-06-23 00:00:00
Day 5
Evansville, Indiana United States Explore the impressive USS LST 325 warship and dive into American military history at this fully restored amphibious vessel.
Arrive 2026-06-23 00:00:00
Day 6
🌊 At Sea
Day 7
Louisville, Kentucky United States Cruise into the birthplace of bourbon and explore the legendary distilleries that shaped American whiskey history.
Arrive 2026-06-25 00:00:00
Day 8
Madison, Indiana United States Explore perfectly preserved Victorian architecture and stroll charming riverfront streets in this gem of a 19th-century river town.
Arrive 2026-06-26 00:00:00
Day 9
Cincinnati, Ohio United States Explore America's most intact Victorian riverfront and discover world-class museums in this historic Ohio River gateway city.
Arrive 2026-06-27 00:00:00
Day 10
🌊 At Sea
Day 11
Maysville, Kentucky United States Trace American frontier history and bourbon heritage along the scenic Ohio River at this charming 19th-century riverport town.
Arrive 2026-06-29 00:00:00
Day 12
🌊 At Sea
Day 13
Marietta, Ohio United States Explore the historic Ohio River confluence where America's frontier began at the Campus Martius Museum and charming riverfront district.
Arrive 2026-07-01 00:00:00
Day 14
🌊 At Sea
Day 15
Pittsburgh, Pennsylvania United States Explore three iconic steel bridges and world-class museums along the scenic confluence of three rivers in America's revitalized Steel City.
Arrive 2026-07-03 00:00:00

About This Cruise

oin us for this 16-Day adventure along the grand Ohio and Mississippi Rivers, where the stories of America unfurl around you. Each port of call brings a fresh encounter with the spirit of Americana, from the quaint riverbanks of Ohio and Kentucky to the industrious spirit of Pittsburgh and the historic charm of St. Louis. Aboard one of our Modern Riverboats, experience the pivotal eras of the Civil War and the Civil Rights Movement as you navigate these iconic waterways. In Henderson, KY, explore the Audubon Museum, a sanctuary of original artworks that illuminate the profound influence of John James Audubon on America’s appreciation for the natural world. Venture further into the creative realms at the National Quilt Museum in Paducah, renowned globally for its extensive and beautifully curated collection of quilt and fiber arts. In Louisville, experience the thrill of Churchill Downs, the heart of the Kentucky Derby, with an exclusive behind-the-scenes look at this hallowed ground of horseracing. As the day wanes, retreat to the comfort and elegance of your ship. Dine in our refined restaurant, where culinary delights meet engaging conversation, and each meal is inspired by the ports you visit. Navigating the Ohio River is an exercise in flexibility and wonder, shaped by the whims of its waters. Our itineraries are crafted with care, yet open to the spontaneous rhythms of river currents. Come aboard for an exquisite encounter with America's iconic rivers, where history and nature dance along the water's edge.
From $6,738 per person 14 nights on American Melody with American Cruise Lines
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