Route Map
Compare Cruise Lines
| Cruise Line | Cruises | Ships | From | Duration | Next Sailing | |
|---|---|---|---|---|---|---|
American Cruise Lines
|
12 | 3 | $6,409 | 14 nights | Jul 2, 2027 |
All Cruises on This Route
- 14-night American Cruise Lines cruise on American Melody from Saint Louis, Missouri
- 14-night American Cruise Lines cruise on American Melody from Pittsburgh, Pennsylvania
- 14-night American Cruise Lines cruise on American Symphony from Pittsburgh, Pennsylvania
- 14-night American Cruise Lines cruise on American Heritage from Pittsburgh, Pennsylvania
Ports on This Route
Cape Girardeau, Missouri
Discover the mighty Mississippi River's history at the Gateway Arch-inspired riverfront while exploring charming downtown shops and authentic regional cuisine.
Cincinnati, Ohio
Explore America's most intact Victorian riverfront and discover world-class museums in this historic Ohio River gateway city.
Evansville, Indiana
Explore the impressive USS LST 325 warship and dive into American military history at this fully restored amphibious vessel.
Henderson, Kentucky
Explore the historic John James Audubon State Park and museum to discover wildlife artistry and Kentucky heritage along the scenic Ohio River.
Louisville, Kentucky
Cruise into the birthplace of bourbon and explore the legendary distilleries that shaped American whiskey history.
Marietta, Ohio
Explore the historic Ohio River confluence where America's frontier began at the Campus Martius Museum and charming riverfront district.
Maysville, Kentucky
Trace American frontier history and bourbon heritage along the scenic Ohio River at this charming 19th-century riverport town.
Paducah, Kentucky
Explore America's largest collection of outdoor murals transforming riverside walls into an open-air art gallery.