Route Map
Price Drops & Deals
Mississippi River Odyssey
Viking River CruisesCompare Cruise Lines
| Cruise Line | Cruises | Ships | From | Duration | Next Sailing | |
|---|---|---|---|---|---|---|
American Cruise Lines
|
32 | 4 | $8,754 | 14-22 nights | Sep 11, 2026 | |
|
Viking River Cruises
|
4 | 1 | $10,795 | 14-21 nights | Sep 5, 2026 |
All Cruises on This Route
- 14-night Viking River Cruises cruise on Viking Mississippi from Saint Paul, Minnesota
- 14-night American Cruise Lines cruise on American Heritage from Saint Paul, Minnesota
- 15-night American Cruise Lines cruise on American Heritage from Saint Paul, Minnesota
- 14-night American Cruise Lines cruise on American Serenade from Saint Paul, Minnesota
- 15-night American Cruise Lines cruise on American Serenade from Saint Paul, Minnesota
- 14-night American Cruise Lines cruise on American Melody from Saint Paul, Minnesota
- 15-night American Cruise Lines cruise on American Melody from Saint Paul, Minnesota
- 22-night American Cruise Lines cruise on American Melody from New Orleans, Louisiana
- 22-night American Cruise Lines cruise on American Serenade from New Orleans, Louisiana
- 21-night Viking River Cruises cruise on Viking Mississippi from New Orleans, Louisiana
- 14-night American Cruise Lines cruise on American Symphony from Saint Paul, Minnesota
- 15-night American Cruise Lines cruise on American Symphony from Saint Paul, Minnesota
Ports on This Route
Baton Rouge, Louisiana
Explore the magnificent Louisiana State Capitol, a 34-story Art Deco masterpiece offering panoramic river views and fascinating political history.
Dubuque, Iowa
Ride the historic riverboat casino and watch the Mississippi River roll by from scenic bluffs that rise 188 feet above the water.
Hannibal, Missouri
Explore the childhood home of Mark Twain and retrace the adventures of Tom Sawyer along the mighty Mississippi River.
Memphis, Tennessee
Dive into musical history at Graceland, Elvis Presley's legendary mansion and the second-most visited private home in America.
Natchez, Mississippi
Tour antebellum mansions perched on bluffs overlooking the Mississippi River where Southern history comes vividly alive.
Saint Louis, Missouri
Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Tunica, Mississippi
Roll the dice at world-class casinos nestled along the Mississippi River in this thrilling gaming destination.
Vicksburg, Mississippi
Explore Civil War battlefields and monuments at this historic riverside bluff that shaped American history.
Davenport, Iowa
Witness the mighty Mississippi River from the Figge Art Museum's stunning riverfront galleries in Iowa's cultural heartland.
La Crosse, Wisconsin
Cruise passengers can ride scenic riverboats through the majestic bluffs of the Upper Mississippi River Valley.
Cape Girardeau, Missouri
Discover the mighty Mississippi River's history at the Gateway Arch-inspired riverfront while exploring charming downtown shops and authentic regional cuisine.
Greenville, Mississippi
Explore the haunting history of the Mississippi Delta where blues music was born and civil rights struggles shaped America's soul.
Houmas House, Louisiana
Explore an opulent antebellum mansion surrounded by sprawling gardens and glimpse Louisiana's grand plantation heritage.
Muscatine, Iowa
Discover the Mississippi River's pearl heritage and stroll charming riverfront trails lined with historic architecture and local art galleries.
Oak Alley, Louisiana
Stroll beneath a majestic canopy of 300-year-old oak trees lining the grand plantation mansion.
Red Wing, Minnesota
Explore the Mississippi River's scenic bluffs and historic riverfront charm at this picturesque Minnesota gem nestled where water and nature converge.
Saint Francisville, Louisiana
Explore stunning antebellum mansions nestled among Spanish moss-draped oaks along the serene Mississippi River bluffs.
Winona, Minnesota
Explore the dramatic bluffs and rich riverboat heritage along the scenic Mississippi River in this charming historic town.