Route Map
Day-by-Day Itinerary
Day 1
New Orleans, Louisiana
United States
Jazz-filled streets and Creole cuisine in the French Quarter transport you to a world where history, music, and flavor dance together.
Arrive
2026-06-13 00:00:00
Day 2
🌊 At Sea
Day 3
Oak Alley, Louisiana
United States
Stroll beneath a majestic canopy of 300-year-old oak trees lining the grand plantation mansion.
Arrive
2026-06-15 00:00:00
Day 4
Houmas House, Louisiana
United States
Explore an opulent antebellum mansion surrounded by sprawling gardens and glimpse Louisiana's grand plantation heritage.
Arrive
2026-06-16 00:00:00
Day 5
Baton Rouge, Louisiana
United States
Explore the magnificent Louisiana State Capitol, a 34-story Art Deco masterpiece offering panoramic river views and fascinating political history.
Arrive
2026-06-17 00:00:00
Day 6
Saint Francisville, Louisiana
United States
Explore stunning antebellum mansions nestled among Spanish moss-draped oaks along the serene Mississippi River bluffs.
Arrive
2026-06-18 00:00:00
Day 7
Natchez, Mississippi
United States
Tour antebellum mansions perched on bluffs overlooking the Mississippi River where Southern history comes vividly alive.
Arrive
2026-06-19 00:00:00
Day 8
Vicksburg, Mississippi
United States
Explore Civil War battlefields and monuments at this historic riverside bluff that shaped American history.
Arrive
2026-06-20 00:00:00
Day 9
Greenville, Mississippi
United States
Explore the haunting history of the Mississippi Delta where blues music was born and civil rights struggles shaped America's soul.
Arrive
2026-06-21 00:00:00
Day 10
Tunica, Mississippi
United States
Roll the dice at world-class casinos nestled along the Mississippi River in this thrilling gaming destination.
Arrive
2026-06-22 00:00:00
Day 11
Memphis, Tennessee
United States
Dive into musical history at Graceland, Elvis Presley's legendary mansion and the second-most visited private home in America.
Arrive
2026-06-23 00:00:00
Day 12
Cape Girardeau, Missouri
United States
Discover the mighty Mississippi River's history at the Gateway Arch-inspired riverfront while exploring charming downtown shops and authentic regional cuisine.
Arrive
2026-06-24 00:00:00
Day 13
🌊 At Sea
Day 14
Saint Louis, Missouri
United States
Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive
2026-06-26 00:00:00
Day 15
🌊 At Sea
Day 16
Hannibal, Missouri
United States
Explore the childhood home of Mark Twain and retrace the adventures of Tom Sawyer along the mighty Mississippi River.
Arrive
2026-06-28 00:00:00
Day 17
🌊 At Sea
Day 18
Muscatine, Iowa
United States
Discover the Mississippi River's pearl heritage and stroll charming riverfront trails lined with historic architecture and local art galleries.
Arrive
2026-06-30 00:00:00
Day 19
Dubuque, Iowa
United States
Ride the historic riverboat casino and watch the Mississippi River roll by from scenic bluffs that rise 188 feet above the water.
Arrive
2026-07-01 00:00:00
Day 20
🌊 At Sea
Day 21
Winona, Minnesota
United States
Explore the dramatic bluffs and rich riverboat heritage along the scenic Mississippi River in this charming historic town.
Arrive
2026-07-03 00:00:00
Day 22
Red Wing, Minnesota
United States
Explore the Mississippi River's scenic bluffs and historic riverfront charm at this picturesque Minnesota gem nestled where water and nature converge.
Arrive
2026-07-04 00:00:00
Day 23
Saint Paul, Minnesota
United States
Explore the Minnesota History Center's impressive collections and stroll through vibrant neighborhoods along the scenic Mississippi River.
Arrive
2026-07-05 00:00:00
About This Cruise
The echoes of riverboat travelers from a bygone era resound as we travel the full length of the Mighty Mississippi. As ten states glide past your vantage point on the sun deck, admire what has been the subject of numerous works of art and the backdrop for countless American novels.From the vibrant cultural center of the “Big Easy” to the dramatic landscapes of the Upper Mississippi, experience life as it once was on the western frontier. Our expert guides will take you to the grand southern plantations, stately antebellum houses, and Civil War battlefields of the Lower Mississippi. Taste the finest Cajun and Creole and enjoy mouth-watering Memphis BBQ as you travel to the birthplace of Jazz, Blues, and Rock–n-Roll.Cruising up the river, Hometown Americana takes center stage. Relive the adventures of Mark Twain’s time on a trolley ride through Hannibal, his boyhood hometown. Experience the legacy of John Deere in Davenport and the Victorian-era elegance of Dubuque. As we continue north, pasture gives way to forest and the wild life of Minnesota and Wisconsin comes into view.Just as it was in Mark Twain’s day, every cruise on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.
From $11,817 per person
22 nights on
American Serenade
with
American Cruise Lines
Visit American
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