Complete Mississippi
Route Map
Day-by-Day Itinerary
Day 1
New Orleans, Louisiana
United States
Jazz-filled streets and Creole cuisine in the French Quarter transport you to a world where history, music, and flavor dance together.
Arrive
2026-06-12 00:00:00
Day 2
New Orleans, Louisiana
United States
Jazz-filled streets and Creole cuisine in the French Quarter transport you to a world where history, music, and flavor dance together.
Arrive
2026-06-13 00:00:00
Day 3
Oak Alley, Louisiana
United States
Stroll beneath a majestic canopy of 300-year-old oak trees lining the grand plantation mansion.
Arrive
2026-06-14 00:00:00
Day 4
Houmas House, Louisiana
United States
Explore an opulent antebellum mansion surrounded by sprawling gardens and glimpse Louisiana's grand plantation heritage.
Arrive
2026-06-15 00:00:00
Day 5
Baton Rouge, Louisiana
United States
Explore the magnificent Louisiana State Capitol, a 34-story Art Deco masterpiece offering panoramic river views and fascinating political history.
Arrive
2026-06-16 00:00:00
Day 6
Saint Francisville, Louisiana
United States
Explore stunning antebellum mansions nestled among Spanish moss-draped oaks along the serene Mississippi River bluffs.
Arrive
2026-06-17 00:00:00
Day 7
Natchez, Mississippi
United States
Tour antebellum mansions perched on bluffs overlooking the Mississippi River where Southern history comes vividly alive.
Arrive
2026-06-18 00:00:00
Day 8
Vicksburg, Mississippi
United States
Explore Civil War battlefields and monuments at this historic riverside bluff that shaped American history.
Arrive
2026-06-19 00:00:00
Day 9
Greenville, Mississippi
United States
Explore the haunting history of the Mississippi Delta where blues music was born and civil rights struggles shaped America's soul.
Arrive
2026-06-20 00:00:00
Day 10
Tunica, Mississippi
United States
Roll the dice at world-class casinos nestled along the Mississippi River in this thrilling gaming destination.
Arrive
2026-06-21 00:00:00
Day 11
Memphis, Tennessee
United States
Dive into musical history at Graceland, Elvis Presley's legendary mansion and the second-most visited private home in America.
Arrive
2026-06-22 00:00:00
Day 12
Cape Girardeau, Missouri
United States
Discover the mighty Mississippi River's history at the Gateway Arch-inspired riverfront while exploring charming downtown shops and authentic regional cuisine.
Arrive
2026-06-23 00:00:00
Day 13
🌊 At Sea
Day 14
Saint Louis, Missouri
United States
Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive
2026-06-25 00:00:00
Day 15
🌊 At Sea
Day 16
Hannibal, Missouri
United States
Explore the childhood home of Mark Twain and retrace the adventures of Tom Sawyer along the mighty Mississippi River.
Arrive
2026-06-27 00:00:00
Day 17
🌊 At Sea
Day 18
Muscatine, Iowa
United States
Discover the Mississippi River's pearl heritage and stroll charming riverfront trails lined with historic architecture and local art galleries.
Arrive
2026-06-29 00:00:00
Day 19
Dubuque, Iowa
United States
Ride the historic riverboat casino and watch the Mississippi River roll by from scenic bluffs that rise 188 feet above the water.
Arrive
2026-06-30 00:00:00
Day 20
🌊 At Sea
Day 21
Winona, Minnesota
United States
Explore the dramatic bluffs and rich riverboat heritage along the scenic Mississippi River in this charming historic town.
Arrive
2026-07-02 00:00:00
Day 22
Red Wing, Minnesota
United States
Explore the Mississippi River's scenic bluffs and historic riverfront charm at this picturesque Minnesota gem nestled where water and nature converge.
Arrive
2026-07-03 00:00:00
About This Cruise
The echoes of riverboat travelers from a bygone era resound as we travel the full length of the Mighty Mississippi. As ten states glide past your vantage point on the sun deck, admire what has been the subject of numerous works of art and the backdrop for countless American novels. From the vibrant cultural center of the “Big Easy” to the bucolic landscapes of the Upper Mississippi, experience life as it once was on the western frontier. Taste the celebrated local cuisine and immerse yourself in the unique essence of each port-of-call. Our onboard experts bring the stories of the River to life and provide context to each shore experience we provide along the way.
From $12,611 per person
21 nights on
American Serenade
with
American Cruise Lines
Visit American
↗
