Grand Heartland Cruise
Saturday, September 25, 2027
Sunday, October 10, 2027
15 Nights
Saint Paul, Minnesota
American Serenade
Route Map
Day-by-Day Itinerary
Day 1
Saint Paul, Minnesota
United States
Explore the Minnesota History Center's impressive collections and stroll through vibrant neighborhoods along the scenic Mississippi River.
Arrive
2027-09-25 00:00:00
Day 2
🌊 At Sea
Day 3
La Crosse, Wisconsin
United States
Cruise passengers can ride scenic riverboats through the majestic bluffs of the Upper Mississippi River Valley.
Arrive
2027-09-27 00:00:00
Day 4
Dubuque, Iowa
United States
Ride the historic riverboat casino and watch the Mississippi River roll by from scenic bluffs that rise 188 feet above the water.
Arrive
2027-09-28 00:00:00
Day 5
Davenport, Iowa
United States
Witness the mighty Mississippi River from the Figge Art Museum's stunning riverfront galleries in Iowa's cultural heartland.
Arrive
2027-09-29 00:00:00
Day 6
🌊 At Sea
Day 7
Hannibal, Missouri
United States
Explore the childhood home of Mark Twain and retrace the adventures of Tom Sawyer along the mighty Mississippi River.
Arrive
2027-10-01 00:00:00
Day 8
🌊 At Sea
Day 9
Saint Louis, Missouri
United States
Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive
2027-10-03 00:00:00
Day 10
Memphis, Tennessee
United States
Dive into musical history at Graceland, Elvis Presley's legendary mansion and the second-most visited private home in America.
Arrive
2027-10-04 00:00:00
Day 11
Tunica, Mississippi
United States
Roll the dice at world-class casinos nestled along the Mississippi River in this thrilling gaming destination.
Arrive
2027-10-05 00:00:00
Day 12
🌊 At Sea
Day 13
Vicksburg, Mississippi
United States
Explore Civil War battlefields and monuments at this historic riverside bluff that shaped American history.
Arrive
2027-10-07 00:00:00
Day 14
Natchez, Mississippi
United States
Tour antebellum mansions perched on bluffs overlooking the Mississippi River where Southern history comes vividly alive.
Arrive
2027-10-08 00:00:00
Day 15
Baton Rouge, Louisiana
United States
Explore the magnificent Louisiana State Capitol, a 34-story Art Deco masterpiece offering panoramic river views and fascinating political history.
Arrive
2027-10-09 00:00:00
Day 16
New Orleans, Louisiana
United States
Jazz-filled streets and Creole cuisine in the French Quarter transport you to a world where history, music, and flavor dance together.
Arrive
2027-10-10 00:00:00
About This Cruise
Enjoy an epic 15-day journey on our Grand Heartland Cruise. This cruise on the Mississippi River travels from the northern reaches of St. Paul all the way down to the basin in New Orleans. View the dramatic landscapes of the Upper Mississippi River which have long inspired artists, writers, and steamboat passengers. Visit Hannibal, the hometown of Mark Twain where the characters in his most popular works come to life. Immerse yourself in the culture of Memphis, the mid-South's most vibrant city, famous for Blues and BBQ. As you journey down the river, hear stories about southern life on the plantation and tour historic Civil War sites led by our local area experts. On your final stop, New Orleans, enjoy privileged access to its vibrant music scene and the best in Cajun and Creole cuisine. Just as it was in Mark Twain’s day, every cruise on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.
From $10,016 per person
15 nights on
American Serenade
with
American Cruise Lines
Visit American
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