Route Map
Day-by-Day Itinerary
Day 1
Saint Louis, Missouri
United States
Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive
2027-07-03 00:00:00
Day 2
Saint Louis, Missouri
United States
Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive
2027-07-04 00:00:00
Day 3
Cape Girardeau, Missouri
United States
Discover the mighty Mississippi River's history at the Gateway Arch-inspired riverfront while exploring charming downtown shops and authentic regional cuisine.
Arrive
2027-07-05 00:00:00
Day 4
🌊 At Sea
Day 5
Paducah, Kentucky
United States
Explore America's largest collection of outdoor murals transforming riverside walls into an open-air art gallery.
Arrive
2027-07-07 00:00:00
Day 6
Evansville, Indiana
United States
Explore the impressive USS LST 325 warship and dive into American military history at this fully restored amphibious vessel.
Arrive
2027-07-08 00:00:00
Day 7
Henderson, Kentucky
United States
Explore the historic John James Audubon State Park and museum to discover wildlife artistry and Kentucky heritage along the scenic Ohio River.
Arrive
2027-07-09 00:00:00
Day 8
Louisville, Kentucky
United States
Cruise into the birthplace of bourbon and explore the legendary distilleries that shaped American whiskey history.
Arrive
2027-07-10 00:00:00
Day 9
Louisville, Kentucky
United States
Cruise into the birthplace of bourbon and explore the legendary distilleries that shaped American whiskey history.
Arrive
2027-07-11 00:00:00
Day 10
Cincinnati, Ohio
United States
Explore America's most intact Victorian riverfront and discover world-class museums in this historic Ohio River gateway city.
Arrive
2027-07-12 00:00:00
Day 11
Cincinnati, Ohio
United States
Explore America's most intact Victorian riverfront and discover world-class museums in this historic Ohio River gateway city.
Arrive
2027-07-13 00:00:00
Day 12
Maysville, Kentucky
United States
Trace American frontier history and bourbon heritage along the scenic Ohio River at this charming 19th-century riverport town.
Arrive
2027-07-14 00:00:00
Day 13
Marietta, Ohio
United States
Explore the historic Ohio River confluence where America's frontier began at the Campus Martius Museum and charming riverfront district.
Arrive
2027-07-15 00:00:00
Day 14
🌊 At Sea
Day 15
Pittsburgh, Pennsylvania
United States
Explore three iconic steel bridges and world-class museums along the scenic confluence of three rivers in America's revitalized Steel City.
Arrive
2027-07-17 00:00:00
About This Cruise
Experience two of America’s greatest rivers on this enchanting cruise through the Heartland. Immerse yourself in a new element of Americana at each port visited, from the small towns of Kentucky and Ohio to the vibrant metropolis of “Steel City” Pittsburg and St. Louis, the Gateway to the West. As you cruise the Ohio River, immerse yourself in our American roots from the Civil War to the Civil Rights Movement. Cruising the legendary Mississippi River, surround yourself with the landscapes and idyllic towns that inspired Mark Twain.While in Louisville, be treated to a behind-the-scenes exploration of Churchill Downs, the site of the famed Kentucky Derby. In Henderson, visit the John James Audubon Museum, which features many of his original works and explore the National Quilt Museum in Paducah, the world's largest museum devoted to quilt and fiber art.
From $7,333 per person
14 nights on
American Melody
with
American Cruise Lines
Visit American
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