Grand Ohio River (St. Louis to Pittsburgh)

📅 Saturday, July 3, 2027 🏁 Saturday, July 17, 2027 🌙 14 Nights Saint Louis, Missouri 🚢 American Melody
Suite $12,881 per person
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Route Map

Day-by-Day Itinerary

Day 1
Saint Louis, Missouri United States Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive 2027-07-03 00:00:00
Day 2
Saint Louis, Missouri United States Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive 2027-07-04 00:00:00
Day 3
Cape Girardeau, Missouri United States Discover the mighty Mississippi River's history at the Gateway Arch-inspired riverfront while exploring charming downtown shops and authentic regional cuisine.
Arrive 2027-07-05 00:00:00
Day 4
🌊 At Sea
Day 5
Paducah, Kentucky United States Explore America's largest collection of outdoor murals transforming riverside walls into an open-air art gallery.
Arrive 2027-07-07 00:00:00
Day 6
Evansville, Indiana United States Explore the impressive USS LST 325 warship and dive into American military history at this fully restored amphibious vessel.
Arrive 2027-07-08 00:00:00
Day 7
Henderson, Kentucky United States Explore the historic John James Audubon State Park and museum to discover wildlife artistry and Kentucky heritage along the scenic Ohio River.
Arrive 2027-07-09 00:00:00
Day 8
Louisville, Kentucky United States Cruise into the birthplace of bourbon and explore the legendary distilleries that shaped American whiskey history.
Arrive 2027-07-10 00:00:00
Day 9
Louisville, Kentucky United States Cruise into the birthplace of bourbon and explore the legendary distilleries that shaped American whiskey history.
Arrive 2027-07-11 00:00:00
Day 10
Cincinnati, Ohio United States Explore America's most intact Victorian riverfront and discover world-class museums in this historic Ohio River gateway city.
Arrive 2027-07-12 00:00:00
Day 11
Cincinnati, Ohio United States Explore America's most intact Victorian riverfront and discover world-class museums in this historic Ohio River gateway city.
Arrive 2027-07-13 00:00:00
Day 12
Maysville, Kentucky United States Trace American frontier history and bourbon heritage along the scenic Ohio River at this charming 19th-century riverport town.
Arrive 2027-07-14 00:00:00
Day 13
Marietta, Ohio United States Explore the historic Ohio River confluence where America's frontier began at the Campus Martius Museum and charming riverfront district.
Arrive 2027-07-15 00:00:00
Day 14
🌊 At Sea
Day 15
Pittsburgh, Pennsylvania United States Explore three iconic steel bridges and world-class museums along the scenic confluence of three rivers in America's revitalized Steel City.
Arrive 2027-07-17 00:00:00

About This Cruise

Experience two of America’s greatest rivers on this enchanting cruise through the Heartland. Immerse yourself in a new element of Americana at each port visited, from the small towns of Kentucky and Ohio to the vibrant metropolis of “Steel City” Pittsburg and St. Louis, the Gateway to the West. As you cruise the Ohio River, immerse yourself in our American roots from the Civil War to the Civil Rights Movement. Cruising the legendary Mississippi River, surround yourself with the landscapes and idyllic towns that inspired Mark Twain. While in Louisville, be treated to a behind-the-scenes exploration of Churchill Downs, the site of the famed Kentucky Derby. In Henderson, visit the John James Audubon Museum, which features many of his original works and explore the National Quilt Museum in Paducah, the world's largest museum devoted to quilt and fiber art.
From $7,333 per person 14 nights on American Melody with American Cruise Lines
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