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Panama City to San Juan (Puerto Rico) Cruises

1 Cruises 1 Cruise Lines

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A Grand Journey through Balmy Shores & Enchanting Nature to Panama’s Wonders

Explora Journeys
EXPLORA III 17 nights Apr 5, 2027
$9,750 $8,645 Save $1,105
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Cruise Line Cruises Ships From Duration Next Sailing
Explora Journeys 1 1 $8,190 17 nights Apr 5, 2027

All Cruises on This Route

Ports on This Route

Cartagena

Wander through centuries-old Mediterranean architecture while savoring fresh seafood in charming plazas overlooking pristine beaches.

Casa de Campo

Explore pristine Caribbean beaches and championship golf courses nestled between lush tropical landscapes and exclusive resort amenities.

San Blas Islands

Dive into crystalline waters to discover untouched coral gardens and pristine beaches ruled by the indigenous Guna people.

Basseterre, Saint Kitts

Ascend the iconic Brimstone Hill Fortress to witness sweeping Caribbean views from one of the Western Hemisphere's most impressive 17th-century strongholds.

Gustavia

Shop world-class boutiques and dine at Michelin-starred restaurants in this ultra-chic Caribbean harbor town.

Key West, Florida

Sunset at Mallory Square transforms the waterfront into a bohemian celebration of street performers, artists, and spectacular tropical colors.

Little Bay

Hike through lush rainforest trails to discover pristine volcanic beaches and dramatic mountain views that showcase Montserrat's wild natural beauty.

Miami, Florida

Dive into the glittering Art Deco architecture and electrifying nightlife of South Beach, Miami's most iconic coastal neighborhood.

Ocho Rios

Cascade down seven terraced waterfalls surrounded by lush rainforest at Dunn's River Falls, Jamaica's most iconic natural wonder.

Oranjestad

Swim with tropical fish at pristine beaches just steps from the colorful Dutch colonial architecture and duty-free shopping of this island gem.

Santa Marta

Trek through lush jungle to discover the mystical terraced ruins of Lost City, one of the world's largest pre-Columbian settlements hidden in the Colombian wilderness.

Willemstad

Wander through the kaleidoscopic pastel architecture of Punda district where centuries-old colonial charm meets Caribbean color on every corner.

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