Point-to-Point

New Orleans, Louisiana to Saint Louis, Missouri Cruises

6 Cruises 2 Cruise Lines

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Cruise Line Cruises Ships From Duration Next Sailing
American Cruise Lines 3 2 $5,048 11 nights Jul 7, 2027
Viking River Cruises 3 1 $5,395 14 nights Jul 6, 2027

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Memphis, Tennessee

Dive into musical history at Graceland, Elvis Presley's legendary mansion and the second-most visited private home in America.

Natchez, Mississippi

Tour antebellum mansions perched on bluffs overlooking the Mississippi River where Southern history comes vividly alive.

Paducah, Kentucky

Explore America's largest collection of outdoor murals transforming riverside walls into an open-air art gallery.

Vicksburg, Mississippi

Explore Civil War battlefields and monuments at this historic riverside bluff that shaped American history.

Baton Rouge, Louisiana

Explore the magnificent Louisiana State Capitol, a 34-story Art Deco masterpiece offering panoramic river views and fascinating political history.

Cape Girardeau, Missouri

Discover the mighty Mississippi River's history at the Gateway Arch-inspired riverfront while exploring charming downtown shops and authentic regional cuisine.

Darrow, Louisiana

Paddle through misty bayou swamps teeming with alligators and ancient cypress trees draped in Spanish moss.

Greenville, Mississippi

Explore the haunting history of the Mississippi Delta where blues music was born and civil rights struggles shaped America's soul.

Saint Francisville, Louisiana

Explore stunning antebellum mansions nestled among Spanish moss-draped oaks along the serene Mississippi River bluffs.

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