Point-to-Point

Louisville, Kentucky to New Orleans, Louisiana Cruises

4 Cruises 1 Cruise Lines

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Cruise Line Cruises Ships From Duration Next Sailing
Viking River Cruises 4 1 $10,190 14 nights Jun 1, 2027
American Cruise Lines 3 1 $6,925 12-14 nights Jul 6, 2027

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Ports on This Route

Darrow, Louisiana

Paddle through misty bayou swamps teeming with alligators and ancient cypress trees draped in Spanish moss.

Greenville, Mississippi

Explore the haunting history of the Mississippi Delta where blues music was born and civil rights struggles shaped America's soul.

Henderson, Kentucky

Explore the historic John James Audubon State Park and museum to discover wildlife artistry and Kentucky heritage along the scenic Ohio River.

Memphis, Tennessee

Dive into musical history at Graceland, Elvis Presley's legendary mansion and the second-most visited private home in America.

Natchez, Mississippi

Tour antebellum mansions perched on bluffs overlooking the Mississippi River where Southern history comes vividly alive.

Owensboro, Kentucky

Discover the rich musical heritage and bourbon craftsmanship that define this charming Ohio River town's unique character.

Paducah, Kentucky

Explore America's largest collection of outdoor murals transforming riverside walls into an open-air art gallery.

Saint Francisville, Louisiana

Explore stunning antebellum mansions nestled among Spanish moss-draped oaks along the serene Mississippi River bluffs.

Vicksburg, Mississippi

Explore Civil War battlefields and monuments at this historic riverside bluff that shaped American history.

Baton Rouge, Louisiana

Explore the magnificent Louisiana State Capitol, a 34-story Art Deco masterpiece offering panoramic river views and fascinating political history.

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