Point-to-Point

Istanbul to Southampton Cruises

1 Cruises 1 Cruise Lines

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Cruise Line Cruises Ships From Duration Next Sailing
Oceania Cruises 1 1 $11,889 47 nights Sep 11, 2027

All Cruises on This Route

Ports on This Route

Lisbon

Ride the iconic yellow tram 28 through winding cobblestone streets and discover pastel-colored neighborhoods steeped in centuries of maritime history.

Alicante

Wander through centuries of history in the atmospheric Santa Barbara Castle perched above the Mediterranean with panoramic coastal views.

Málaga

Wander through whitewashed villages clinging to dramatic cliffs while sipping crisp mountain wines in Spain's legendary Andalusian heartland.

Barcelona

Wander through whimsical architectural masterpieces and vibrant Gothic quarters where Gaudí's genius meets Mediterranean charm.

Piraeus

Wander through the Acropolis to stand before the magnificent Parthenon overlooking Athens and the sparkling Aegean Sea.

Porto

Wander through azulejo-tiled medieval streets and taste port wine straight from historic cellars perched above the Douro River.

La Coruña

Marvel at the iconic Tower of Hercules, the world's oldest lighthouse still in use, standing sentinel over dramatic Atlantic cliffs.

La Rochelle

Climb the iconic medieval towers rising from the harbor to discover panoramic Atlantic views and centuries of maritime history.

Vigo

Wander through centuries-old granite streets in the medieval Old Town, where Galician culture and Atlantic seafood traditions come alive.

Livorno

Wander through the Renaissance masterpiece of Pisa's Leaning Tower, just 25 minutes away by train from this charming Tuscan port city.

Argostoli

Dive into the luminescent Melissani Cave Lake where turquoise waters glow beneath a stunning stalactite-studded ceiling.

Marseille

Explore the otherworldly Calanques National Park where towering limestone cliffs plunge into turquoise Mediterranean waters perfect for swimming and kayaking.

Bilbao

Marvel at Frank Gehry's breathtaking titanium Guggenheim Museum, a masterpiece that redefined modern architecture and transformed Bilbao into a cultural destination.

Páros

Wander marble-white villages clinging to cliffsides while savoring fresh seafood overlooking the glittering Aegean Sea.

Catania

Wander through baroque plazas and climb Mount Etna, Europe's most active volcano towering majestically over Sicily's charming coastal city.

Pauillac

Tour world-renowned vineyards and taste exceptional Bordeaux wines in the heart of France's most prestigious wine region.

Gijón

Explore the charming historic old town with its colorful waterfront cafes and pristine beaches that blend Asturian culture with Atlantic coastal beauty.

Gythio

Explore the enchanting Peloponnese where Byzantine castles meet crystal-clear Mediterranean waters perfect for swimming and sailing adventures.

Valencia

Wander through the futuristic City of Arts and Sciences, a stunning architectural marvel that rises like a spaceship from the heart of Valencia.

Valletta

Wander through magnificent baroque palaces and honey-colored limestone streets in Europe's smallest capital, a UNESCO World Heritage fortress city.

La Spezia

Wander through the enchanting villages of Cinque Terre clinging to dramatic cliffs and colorful seaside charm just minutes away.

Vólos

Wander through charming tavernas in the waterfront quarter while gazing at the Pelion Mountains rising dramatically behind this enchanting Thessalian port.

Le Havre

Explore the architectural masterpiece of the UNESCO-listed city rebuilt after WWII, showcasing modernist design and cultural richness.

Zeebrugge

Explore centuries of maritime history at the D-Day Memorial and Museum, then wander charming cobblestone streets lined with Belgian chocolate shops and cozy breweries.

Le Verdon-sur-Mer

Explore the majestic châteaux of Bordeaux wine country and taste world-renowned vintages just minutes from the port.

Agadir

Wander the vibrant souks and relax on pristine Atlantic beaches where desert meets sea.

Algeciras

Glimpse Africa across the Strait of Gibraltar from Europe's southernmost tip while exploring centuries of Moorish heritage.

Mahón, Menorca

Explore Europe's deepest natural harbor surrounded by 18th-century fortifications and charming Mediterranean architecture.

Almería

Wander through the dramatic fortress-crowned old town where Moorish heritage meets sun-drenched Mediterranean charm and pristine beaches.

Milos

Kayak through luminous sea caves and swim in crystal waters beneath dramatic pastel-colored cliffs carved by millennia of volcanic activity.

Monaco

Wander through the opulent Prince's Palace and Casino before savoring Michelin-starred dining in Europe's most glamorous microstate.

Bozcaada

Wine-tasting at centuries-old vineyards overlooking the Aegean Sea captures the essence of this charming Turkish island escape.

Mykonos

Dance until dawn in legendary beach clubs where Mediterranean sunsets meet world-class DJs and crystal-clear waters.

Bremerhaven

Explore the German Emigration Museum to trace millions of ancestors who departed for the New World from this historic port city.

Newhaven/Edinburgh

Wander Edinburgh's cobblestone Royal Mile past medieval closes and crowned with the magnificent hilltop castle overlooking the entire city.

Cádiz

Wander the oldest continuously inhabited city in Western Europe where golden beaches meet centuries of Moorish architecture and sherry wine traditions.

Palermo

Wander through the chaotic Vucciria Market where vendors hawk fresh seafood and street food that tastes like Sicily's salty soul.

Çanakkale

Explore the ancient ruins of Troy, a UNESCO World Heritage Site where Homer's legendary Trojan War unfolded millennia ago.

Palma de Mallorca

Wander through the stunning Gothic cathedral rising from turquoise waters and explore centuries of Mediterranean charm in this vibrant island capital.

Cartagena

Wander through centuries-old Mediterranean architecture while savoring fresh seafood in charming plazas overlooking pristine beaches.

Casablanca

Explore the stunning Hassan II Mosque with its towering minaret overlooking the Atlantic Ocean and intricate Islamic architecture.

Pátmos

Ascend to the mountaintop Monastery of Saint John the Theologian, where Byzantine treasures and panoramic Aegean views reward every step.

Civitavecchia

Wander through Rome's ancient Colosseum and Vatican treasures just an hour from the coast.

Corfu

Wander the enchanting Venetian Old Town with its pastel-colored buildings and dramatic fortress perched above turquoise Ionian waters.

Portimão

Kayak through golden limestone cliffs and secret sea caves sculpted by centuries of Atlantic waves.

Ferrol

Explore the historic Arsenal and shipyards where Spain's naval legacy comes alive through centuries of maritime craftsmanship and innovation.

Rhodes

Wander the medieval streets of the Old Town and stand before the legendary Palace of the Grand Masters, where crusader history comes alive.

Rijeka

Wander through centuries-old Austro-Hungarian architecture while savoring fresh seafood at harborside cafes overlooking the sparkling Adriatic Sea.

Hamburg

Explore Europe's largest port where historic ships sail past cutting-edge modern architecture along the scenic Elbe River.

Rotterdam

Explore the futuristic Euromast tower for panoramic views, then wander historic neighborhoods filled with world-class museums and innovative architecture.

Heraklion (Iraklion), Crete

Wander through the legendary Palace of Knossos to discover Europe's oldest civilization and the mythical home of King Minos.

Saint-Jean-de-Luz

Wander the charming Basque old town with colorful half-timbered houses and savor fresh seafood overlooking a pristine sandy beach.

Hvar Island

Wander the lavender-covered hills and medieval stone streets while sipping world-class wines overlooking the sparkling Adriatic Sea.

Saint-Tropez

Stroll the glamorous harbor lined with luxury yachts, then escape to sun-drenched beaches where French Riviera elegance meets Mediterranean charm.

Ibiza

Dance until sunrise at legendary nightclubs where world-famous DJs transform the island into the Mediterranean's most electrifying party destination.

Salerno

Wander through pastel-colored villages clinging to dramatic cliffs along the breathtaking Amalfi Coast.

Sarandë

Dive into crystal-clear turquoise waters to explore sunken ancient ruins and vibrant underwater caves along the Ionian coast.

IJmuiden

Explore the iconic North Sea Canal and visit the impressive Delta Works fortifications that reveal centuries of Dutch maritime heritage.

Siracuse, Sicily

Wander through ancient Greek temples and baroque palaces in this UNESCO-listed island city where history literally surrounds every sun-drenched corner.

Izmir

Wander through ancient Greek ruins at Ephesus, one of the world's best-preserved archaeological sites, just a short drive from the port.

Sorrento

Wander cliffside piazzas draped in lemon trees while gazing across the glittering Bay of Naples toward Mount Vesuvius.

Khania

Wander through pastel-colored Venetian buildings and dine on fresh seafood overlooking the iconic lighthouse at this romantic Mediterranean harbor.

Trieste

Wander through centuries of Austro-Hungarian grandeur in the elegant piazzas and ornate palaces of this captivating Mediterranean port city.

Kusadasi

Wander through the marble columns of Ephesus, one of antiquity's greatest cities, just steps away from your ship.

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