Upper Mississippi River Cruise (St. Louis to St. Paul)
Route Map
Day-by-Day Itinerary
Day 1
Saint Louis, Missouri
United States
Gaze up at the iconic Gateway Arch while strolling the revitalized riverfront that seamlessly blends St. Louis's rich history with modern urban charm.
Arrive
2027-07-24 00:00:00
Day 2
🌊 At Sea
Day 3
Hannibal, Missouri
United States
Explore the childhood home of Mark Twain and retrace the adventures of Tom Sawyer along the mighty Mississippi River.
Arrive
2027-07-26 00:00:00
Day 4
🌊 At Sea
Day 5
Muscatine, Iowa
United States
Discover the Mississippi River's pearl heritage and stroll charming riverfront trails lined with historic architecture and local art galleries.
Arrive
2027-07-28 00:00:00
Day 6
Dubuque, Iowa
United States
Ride the historic riverboat casino and watch the Mississippi River roll by from scenic bluffs that rise 188 feet above the water.
Arrive
2027-07-29 00:00:00
Day 7
Winona, Minnesota
United States
Explore the dramatic bluffs and rich riverboat heritage along the scenic Mississippi River in this charming historic town.
Arrive
2027-07-30 00:00:00
Day 8
Red Wing, Minnesota
United States
Explore the Mississippi River's scenic bluffs and historic riverfront charm at this picturesque Minnesota gem nestled where water and nature converge.
Arrive
2027-07-31 00:00:00
Day 9
Saint Paul, Minnesota
United States
Explore the Minnesota History Center's impressive collections and stroll through vibrant neighborhoods along the scenic Mississippi River.
Arrive
2027-08-01 00:00:00
About This Cruise
The dramatic landscapes of the Upper Mississippi River have long inspired artists, writers, and steamboat passengers. It was here that literary great Mark Twain used the majestic river and its scenic bluffs as the settings in his most popular works. Visit his boyhood home in Hannibal, where the characters of Huck Finn, Tom Sawyer, and Becky Thatcher come to life. Explore the beautiful gardens and historic homes of La Crosse. Get close to nature in Red Wing as you witness a variety of bald eagle nests. Enjoy a guided tour of the Black Hawk State Historic Site which celebrates the story of the Sauk and Meskwaki Indians who once called Davenport home. Just as it was in Mark Twain’s day, every cruise on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.
From $4,472 per person
8 nights on
American Serenade
with
American Cruise Lines
Visit American
↗
